Energy coupling in DNA gyrase and the mechanism of action of novobiocin

Escherichia coli DNA gyrase catalyzes negative supercoiling of closed duplex DNA at the expense of ATP. Two additional activities of the enzyme that have illuminated the energy coupling component of the supercoiling reaction are the DNA-dependent hydrolysis of ATP to ADP and P(i) and the alteration...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Sugino, Akio, Higgins, N. Patrick, Brown, Patrick O., Peebles, Craig L., Cozzarelli, Nicholas R.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1978
Schlagworte:	Biological Sciences: Biochemistry
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC336216/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/368801/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.10.4838
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