Role of 20-HETE in the antihypertensive effect of transfer of chromosome 5 from Brown Norway to Dahl salt-sensitive rats

This study examined whether substitution of chromosome 5 containing the CYP4A genes from Brown Norway rat onto the Dahl S salt-sensitive (SS) genetic background upregulates the renal production of 20-HETE and attenuates the development of hypertension. The expression of CYP4A protein and the product...

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Autori principali: Williams, Jan M., Fan, Fan, Murphy, Sydney, Schreck, Carlos, Lazar, Jozef, Jacob, Howard J., Roman, Richard J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2012
Soggetti:
Fluid and Electrolyte Homeostasis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362151/
https://ncbi.nlm.nih.gov/pubmed/22442195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00604.2011
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