Adenoviral short hairpin RNA therapy targeting phosphodiesterase 5a relieves cardiac remodeling and dysfunction following myocardial infarction

We previously showed that treatment with tadalafil, a long-acting phosphodiesterase-5a (PDE5a) inhibitor, effectively prevented adverse left ventricular (LV) remodeling of the infarcted heart. We hypothesized that short-hairpin RNA (shRNA) therapy targeting PDE5a would simulate the effects of pharma...

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Detalhes bibliográficos
Main Authors: Li, Longhu, Haider, Husnain Kh., Wang, Linlin, Lu, Gang, Ashraf, Muhammad
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Integrative Cardiovascular Physiology and Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362110/
https://ncbi.nlm.nih.gov/pubmed/22447941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00339.2011
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