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Sca-1(+) stem cell survival and engraftment in the infarcted heart: dual role for preconditioning induced connexin-43
BACKGROUND: We report that elevated connexin-43 (Cx-43) in stem cells preconditioned with insulin like growth factor-1 (IGF-1) is cytoprotective and reprograms the cells for cardiomyogenic differentiation. METHODS AND RESULTS: Sca-1(+) cells were preconditioned with 100nM IGF-1 for 30-minutes follow...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2839162/ https://ncbi.nlm.nih.gov/pubmed/19414636 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.108.827691 |
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