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Subcellular preconditioning of stem cells: mito-Cx43 gene targeting is cytoprotective via shift of mitochondrial Bak and Bcl-xL balance

AIM: To achieve mitochondria-specific expression of connexin-43 (Cx43) transgene for mitochondrial preconditioning in stem cells to improve their survival post-transplantation during heart cell therapy. METHODS & RESULTS: Cx43- or GFP-encoding adenoviral vectors with a mitochondrial targeting se...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lu, Gang, Jiang, Shujia, Ashraf, Muhammad, Haider, Khawaja Husnain
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380626/
https://ncbi.nlm.nih.gov/pubmed/22594326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/rme.12.13
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