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Subcellular preconditioning of stem cells: mito-Cx43 gene targeting is cytoprotective via shift of mitochondrial Bak and Bcl-xL balance
AIM: To achieve mitochondria-specific expression of connexin-43 (Cx43) transgene for mitochondrial preconditioning in stem cells to improve their survival post-transplantation during heart cell therapy. METHODS & RESULTS: Cx43- or GFP-encoding adenoviral vectors with a mitochondrial targeting se...
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| Asıl Yazarlar: | , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2012
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3380626/ https://ncbi.nlm.nih.gov/pubmed/22594326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/rme.12.13 |
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