Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults

Skeletal muscle atrophy during bed rest is attributed, at least in part, to slower basal muscle protein synthesis (MPS). Essential amino acids (EAA) stimulate mammalian target of rapamycin (mTORC1) signaling, amino acid transporter expression, and MPS and are necessary for muscle mass maintenance, b...

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Hauptverfasser: Drummond, Micah J., Dickinson, Jared M., Fry, Christopher S., Walker, Dillon K., Gundermann, David M., Reidy, Paul T., Timmerman, Kyle L., Markofski, Melissa M., Paddon-Jones, Douglas, Rasmussen, Blake B., Volpi, Elena
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2012
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361979/
https://ncbi.nlm.nih.gov/pubmed/22338078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00603.2011
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