Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

Autophagy is a lysosome-dependent degradative process that protects cancer cells from multiple stresses. In preclinical models, autophagy inhibition with chloroquine (CQ) derivatives augments the efficacy of many anticancer therapies, but CQ has limited activity as a single agent. Clinical trials ar...

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Main Authors: McAfee, Quentin, Zhang, Zhihui, Samanta, Arabinda, Levi, Samuel M., Ma, Xiao-Hong, Piao, Shengfu, Lynch, John P., Uehara, Takeshi, Sepulveda, Antonia R., Davis, Lisa E., Winkler, Jeffrey D., Amaravadi, Ravi K.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2012
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361415/
https://ncbi.nlm.nih.gov/pubmed/22566612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118193109
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