Memory B cells are a more reliable archive for historical antimalarial responses than plasma antibodies in no-longer exposed children

Humans respond to foreign antigen by generating plasma Abs and memory B cells (MBCs). The Ab response then declines, sometimes to below the limit of detection. In contrast, MBCs are generally thought to be long-lived. We tested and compared Plasmodium falciparum (Pf)-specific Ab and MBC responses in...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Ndungu, Francis Maina, Olotu, Ally, Mwacharo, Jedidah, Nyonda, Mary, Apfeld, Jordan, Mramba, Lazarus K., Fegan, Gregory W., Bejon, Philip, Marsh, Kevin
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: National Academy of Sciences 2012
Θέματα:
Biological Sciences
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361387/
https://ncbi.nlm.nih.gov/pubmed/22566630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200472109
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