Circumsporozoite-Specific T Cell Responses in Children Vaccinated with RTS,S/AS01(E) and Protection against P falciparum Clinical Malaria

BACKGROUND: RTS,S/AS01(E) is the lead candidate pre-erythrocytic malaria vaccine. In Phase IIb field trials the safety profile was acceptable and the efficacy was 53% (95%CI 31%–72%) for protecting children against clinical malaria caused by P. falciparum. We studied CS-specific T cell responses in...

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Detalhes bibliográficos
Main Authors: Olotu, Ally, Moris, Philippe, Mwacharo, Jedidah, Vekemans, Johan, Kimani, Domtila, Janssens, Michel, Kai, Oscar, Jongert, Erik, Lievens, Marc, Leach, Amanda, Villafana, Tonya, Savarese, Barbara, Marsh, Kevin, Cohen, Joe, Bejon, Philip
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188575/
https://ncbi.nlm.nih.gov/pubmed/21998698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025786
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