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Copper Dependence of Angioproliferation in Pulmonary Arterial Hypertension in Rats and Humans

Obliteration of the vascular lumen by endothelial cell growth is a hallmark of many forms of severe pulmonary arterial hypertension. Copper plays a significant role in the control of endothelial cell proliferation in cancer and wound-healing. We sought to determine whether angioproliferation in rats...

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Detalhes bibliográficos
Main Authors: Bogaard, Harm J., Mizuno, Shiro, Guignabert, Christophe, Al Hussaini, Aysar A., Farkas, Daniela, Ruiter, Gerrina, Kraskauskas, Donatas, Fadel, Elie, Allegood, Jeremy C., Humbert, Marc, Noordegraaf, Anton Vonk, Spiegel, Sarah, Farkas, Laszlo, Voelkel, Norbert F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361355/
https://ncbi.nlm.nih.gov/pubmed/22162909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2011-0296OC
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