Features of “All LNA” Duplexes Showing a New Type of Nucleic Acid Geometry

“Locked nucleic acids” (LNAs) belong to the backbone-modified nucleic acid family. The 2′-O,4′-C-methylene-β-D-ribofuranose nucleotides are used for single or multiple substitutions in RNA molecules and thereby introduce enhanced bio- and thermostability. This renders LNAs powerful tools for diagnos...

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Hlavní autoři: Förster, Charlotte, Eichert, André, Oberthür, Dominik, Betzel, Christian, Geßner, Reinhard, Nitsche, Andreas, Fürste, Jens P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361345/
https://ncbi.nlm.nih.gov/pubmed/22666550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/156035
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