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Crystallization and X-ray diffraction analysis of an ‘all-locked’ nucleic acid duplex derived from a tRNA(Ser) microhelix
Modified nucleic acids are of great interest with respect to their nuclease resistance and enhanced thermostability. In therapeutical and diagnostic applications, such molecules can substitute for labile natural nucleic acids that are targeted against particular diseases or applied in gene therapy....
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
International Union of Crystallography
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2720340/ https://ncbi.nlm.nih.gov/pubmed/19652346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309109026281 |
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