Identification of novel genetic variants in phosphodiesterase 8B (PDE8B), a cAMP specific phosphodiesterase highly expressed in the adrenal cortex, in a cohort of patients with adrenal tumors

BACKGROUND: Genetic aberrations in various components of cAMP signalling pathway predispose to endocrine tumors. Growing evidence has shown that mutations in the phosphodiesterases (PDEs) are involved in the predisposition to adrenocortical neoplastic conditions. OBJECTIVE: Screen for genetic variat...

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Główni autorzy: Rothenbuhler, Anya, Horvath, Anelia, Libé, Rossella, Faucz, Fabio Rueda, Fratticci, Amato, Sanson, Marie Laure Raffin, Vezzosi, Delphine, Azevedo, Monalisa, Levi, Isaak, Almeida, Madson Q, Lodish, Maya, Nesterova, Maria, Bertherat, Jérôme, Stratakis, Constantine A
Format: Artigo
Język:Inglês
Wydane: 2012
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Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360985/
https://ncbi.nlm.nih.gov/pubmed/22335482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2265.2012.04366.x
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