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Direct Formation of the C5′-Radical in the Sugar-Phosphate Backbone of DNA by High Energy Radiation

Neutral sugar radicals formed in DNA sugar-phosphate backbone are well-established as precursors of biologically important damage such as DNA-strand scission and crosslinking. In this work, we present electron spin resonance (ESR) evidence showing that the sugar radical at C5′ (C5′•) is one of the m...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Adhikary, Amitava, Becker, David, Palmer, Brian J., Heizer, Alicia N., Sevilla, Michael D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360814/
https://ncbi.nlm.nih.gov/pubmed/22553971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp3023919
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