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Functional Analysis of a Breast Cancer-Associated Mutation in the Intracellular Domain of the Metalloprotease ADAM12

A recently identified breast cancer-associated mutation in the metalloprotease ADAM12 alters a potential dileucine trafficking signal, which could affect protein processing and cellular localization. ADAM12 belongs to the group of A Disintegrin And Metalloproteases (ADAMs), which are typically membr...

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Main Authors: Stautz, Dorte, Wewer, Ulla M., Kveiborg, Marie
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360752/
https://ncbi.nlm.nih.gov/pubmed/22662180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037628
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