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BREAST CANCER-ASSOCIATED MUTATIONS IN METALLOPROTEASE DISINTEGRIN ADAM12 INTERFERE WITH THE INTRACELLULAR TRAFFICKING AND PROCESSING OF THE PROTEIN
ADAM12 has recently emerged as a Candidate Cancer Gene in a comprehensive genetic analysis of human breast cancers. Three somatic mutations in ADAM12 were observed at significant frequencies in breast cancers: D301H, G479E, and L792F. The first two of these mutations involve highly conserved residue...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2636846/ https://ncbi.nlm.nih.gov/pubmed/18241035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.23405 |
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