Nilotinib Counteracts P-Glycoprotein-Mediated Multidrug Resistance and Synergizes the Antitumoral Effect of Doxorubicin in Soft Tissue Sarcomas

The therapeutic effect of doxorubicin (DXR) in the treatment of soft tissue sarcomas (STS) is limited by its toxicity and the development of multidrug resistance (MDR), the latter mainly induced by high expression of efflux pumps (e.g., P-glycoprotein [P-gp]). Therefore, the search for alternative t...

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Autores principales: Villar, Victor Hugo, Vögler, Oliver, Martínez-Serra, Jordi, Ramos, Rafael, Calabuig-Fariñas, Silvia, Gutiérrez, Antonio, Barceló, Francisca, Martín-Broto, Javier, Alemany, Regina
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360613/
https://ncbi.nlm.nih.gov/pubmed/22662203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037735
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