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Down-Regulation of AKT Signalling by Ursolic Acid Induces Intrinsic Apoptosis and Sensitization to Doxorubicin in Soft Tissue Sarcoma

Several important biological activities have been attributed to the pentacyclic triterpene ursolic acid (UA), being its antitumoral effect extensively studied in human adenocarcinomas. In this work, we focused on the efficacy and molecular mechanisms involved in the antitumoral effects of UA, as sin...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Villar, Victor Hugo, Vögler, Oliver, Barceló, Francisca, Martín-Broto, Javier, Martínez-Serra, Jordi, Ruiz-Gutiérrez, Valentina, Alemany, Regina
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878803/
https://ncbi.nlm.nih.gov/pubmed/27219337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155946
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