Down-Regulation of AKT Signalling by Ursolic Acid Induces Intrinsic Apoptosis and Sensitization to Doxorubicin in Soft Tissue Sarcoma

Several important biological activities have been attributed to the pentacyclic triterpene ursolic acid (UA), being its antitumoral effect extensively studied in human adenocarcinomas. In this work, we focused on the efficacy and molecular mechanisms involved in the antitumoral effects of UA, as sin...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Villar, Victor Hugo, Vögler, Oliver, Barceló, Francisca, Martín-Broto, Javier, Martínez-Serra, Jordi, Ruiz-Gutiérrez, Valentina, Alemany, Regina
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878803/
https://ncbi.nlm.nih.gov/pubmed/27219337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155946
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