Down-Regulation of AKT Signalling by Ursolic Acid Induces Intrinsic Apoptosis and Sensitization to Doxorubicin in Soft Tissue Sarcoma

Several important biological activities have been attributed to the pentacyclic triterpene ursolic acid (UA), being its antitumoral effect extensively studied in human adenocarcinomas. In this work, we focused on the efficacy and molecular mechanisms involved in the antitumoral effects of UA, as sin...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Villar, Victor Hugo, Vögler, Oliver, Barceló, Francisca, Martín-Broto, Javier, Martínez-Serra, Jordi, Ruiz-Gutiérrez, Valentina, Alemany, Regina
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2016
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878803/
https://ncbi.nlm.nih.gov/pubmed/27219337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155946
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