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Widespread recognition of 5′ splice sites by noncanonical base-pairing to U1 snRNA involving bulged nucleotides

An established paradigm in pre-mRNA splicing is the recognition of the 5′ splice site (5′ss) by canonical base-pairing to the 5′ end of U1 small nuclear RNA (snRNA). We recently reported that a small subset of 5′ss base-pair to U1 in an alternate register that is shifted by 1 nucleotide. Using genet...

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Main Authors: Roca, Xavier, Akerman, Martin, Gaus, Hans, Berdeja, Andrés, Bennett, C. Frank, Krainer, Adrian R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Cold Spring Harbor Laboratory Press 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360564/
https://ncbi.nlm.nih.gov/pubmed/22588721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.190173.112
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