TLR2, TLR4 and the MYD88 Signaling Pathway Are Crucial for Neutrophil Migration in Acute Kidney Injury Induced by Sepsis

The aim of this study was to investigate the role of TLR2, TLR4 and MyD88 in sepsis-induced AKI. C57BL/6 TLR2(−/−), TLR4(−/−) and MyD88(−/−) male mice were subjected to sepsis by cecal ligation and puncture (CLP). Twenty four hours later, kidney tissue and blood samples were collected for analysis....

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Hauptverfasser: Castoldi, Angela, Braga, Tárcio Teodoro, Correa-Costa, Matheus, Aguiar, Cristhiane Fávero, Bassi, Ênio José, Correa-Silva, Reinaldo, Elias, Rosa Maria, Salvador, Fábia, Moraes-Vieira, Pedro Manoel, Cenedeze, Marcos Antônio, Reis, Marlene Antônia, Hiyane, Meire Ioshie, Pacheco-Silva, Álvaro, Gonçalves, Giselle Martins, Câmara, Niels Olsen Saraiva
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360043/
https://ncbi.nlm.nih.gov/pubmed/22655058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037584
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