MyD88 Signaling Pathway Is Involved in Renal Fibrosis by Favoring a T(H)2 Immune Response and Activating Alternative M2 Macrophages

Inflammation contributes to the pathogenesis of chronic kidney disease (CKD). Molecules released by the inflamed injured tissue can activate toll-like receptors (TLRs), thereby modulating macrophage and CD4(+) T-cell activity. We propose that in renal fibrogenesis, M2 macrophages are recruited and a...

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Main Authors: Braga, Tarcio Teodoro, Correa-Costa, Matheus, Guise, Yuri Felipe Souza, Castoldi, Angela, de Oliveira, Cassiano Donizetti, Hyane, Meire Ioshie, Cenedeze, Marcos Antonio, Teixeira, Simone Aparecida, Muscara, Marcelo Nicolas, Perez, Katia Regina, Cuccovia, Iolanda Midea, Pacheco-Silva, Alvaro, Gonçalves, Giselle Martins, Camara, Niels Olsen Saraiva
Format: Artigo
Language:Inglês
Published: ScholarOne 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510298/
https://ncbi.nlm.nih.gov/pubmed/22777483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2012.00131
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