EMT Inducers Catalyze Malignant Transformation of Mammary Epithelial Cells and Drive Tumorigenesis towards Claudin-Low Tumors in Transgenic Mice

The epithelial-mesenchymal transition (EMT) is an embryonic transdifferentiation process consisting of conversion of polarized epithelial cells to motile mesenchymal ones. EMT–inducing transcription factors are aberrantly expressed in multiple tumor types and are known to favor the metastatic dissem...

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Auteurs principaux: Morel, Anne-Pierre, Hinkal, George W., Thomas, Clémence, Fauvet, Frédérique, Courtois-Cox, Stéphanie, Wierinckx, Anne, Devouassoux-Shisheboran, Mojgan, Treilleux, Isabelle, Tissier, Agnès, Gras, Baptiste, Pourchet, Julie, Puisieux, Isabelle, Browne, Gareth J., Spicer, Douglas B., Lachuer, Joël, Ansieau, Stéphane, Puisieux, Alain
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
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Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359981/
https://ncbi.nlm.nih.gov/pubmed/22654675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002723
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