Deletion of Apoptosis Signal–Regulating Kinase–1 Prevents Ventilator-Induced Lung Injury in Mice

Both hyperoxia and mechanical ventilation can independently cause lung injury. In combination, these insults produce accelerated and severe lung injury. We recently reported that pre-exposure to hyperoxia for 12 hours, followed by ventilation with large tidal volumes, induced significant lung injury...

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Autori principali: Makena, Patrudu S., Gorantla, Vijay K., Ghosh, Manik C., Bezawada, Lavanya, Kandasamy, Kathirvel, Balazs, Louisa, Luellen, Charlean L., Thompson, Karin E., Parthasarathi, Kaushik, Ichijo, Hidenori, Waters, Christopher M., Sinclair, Scott E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Thoracic Society 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359950/
https://ncbi.nlm.nih.gov/pubmed/22052879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2011-0234OC
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