FGF21 Is Increased by Inflammatory Stimuli and Protects Leptin-Deficient ob/ob Mice from the Toxicity of Sepsis

The acute phase response (APR) produces marked alterations in lipid and carbohydrate metabolism including decreasing plasma ketone levels. Fibroblast growth factor 21 (FGF21) is a recently discovered hormone that regulates lipid and glucose metabolism and stimulates ketogenesis. Here we demonstrate...

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Main Authors: Feingold, Kenneth R., Grunfeld, Carl, Heuer, Josef G., Gupta, Akanksha, Cramer, Martin, Zhang, Tonghai, Shigenaga, Judy K., Patzek, Sophie M., Chan, Zoe W., Moser, Arthur, Bina, Holly, Kharitonenkov, Alexei
Format: Artigo
Jezik:Inglês
Izdano: Endocrine Society 2012
Teme:
General Endocrinology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359613/
https://ncbi.nlm.nih.gov/pubmed/22474187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-1496
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