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Reconstitution of leucine-mediated autophagy via the mTORC1-Barkor pathway in vitro
Supplementation of branched chain amino acids, especially leucine, is critical to improve malnutrition by regulating protein synthesis and degradation. Emerging evidence has linked leucine deprivation induced protein breakdown to autophagy. In this study, we aimed to establish a cell-free assay reca...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Landes Bioscience
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3359502/ https://ncbi.nlm.nih.gov/pubmed/22258093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.8.2.18563 |
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