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Sildenafil, a phosphodiesterase type 5 inhibitor, enhances the antidepressant activity of amitriptyline but not desipramine, in the forced swim test in mice

The cholinergic theory of depression highlights the involvement of muscarinic acetylcholine receptors in the neurobiology of mood disorders. The present study was designed to investigate the effect of sildenafil, a phosphodiesterase type 5 inhibitor which exhibits cholinomimetic properties, alone an...

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Sonraí Bibleagrafaíochta
Main Authors: Socała, Katarzyna, Nieoczym, Dorota, Wyska, Elżbieta, Poleszak, Ewa, Wlaź, Piotr
Formáid: Artigo
Teanga:Inglês
Foilsithe: Springer Vienna 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359440/
https://ncbi.nlm.nih.gov/pubmed/22215207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00702-011-0756-9
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