M. tuberculosis Induces Potent Activation of IDO-1, but This Is Not Essential for the Immunological Control of Infection

Indoleamine 2,3-dioxygenesae-1 (IDO-1) catalyses the initial, rate-limiting step in tryptophan metabolism, thereby regulating tryptophan availability and the formation of downstream metabolites, including picolinic and quinolinic acid. We found that Mycobacterium tuberculosis infection induced marke...

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Detalhes bibliográficos
Main Authors: Blumenthal, Antje, Nagalingam, Gayathri, Huch, Jennifer H., Walker, Lara, Guillemin, Gilles J., Smythe, George A., Ehrt, Sabine, Britton, Warwick J., Saunders, Bernadette M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359358/
https://ncbi.nlm.nih.gov/pubmed/22649518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037314
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