Low Levels of Human HIP14 Are Sufficient to Rescue Neuropathological, Behavioural, and Enzymatic Defects Due to Loss of Murine HIP14 in Hip14−/− Mice

Huntingtin Interacting Protein 14 (HIP14) is a palmitoyl acyl transferase (PAT) that was first identified due to altered interaction with mutant huntingtin, the protein responsible for Huntington Disease (HD). HIP14 palmitoylates a specific set of neuronal substrates critical at the synapse, and dow...

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Main Authors: Young, Fiona B., Franciosi, Sonia, Spreeuw, Amanda, Deng, Yu, Sanders, Shaun, Tam, Natalie C. M., Huang, Kun, Singaraja, Roshni R., Zhang, Weining, Bissada, Nagat, Kay, Chris, Hayden, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359340/
https://ncbi.nlm.nih.gov/pubmed/22649491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036315
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