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Differences in intradomain and interdomain motion confer distinct activation properties to structurally similar Gα proteins
Proteins with similar crystal structures can have dissimilar rates of substrate binding and catalysis. Here we used molecular dynamics simulations and biochemical analysis to determine the role of intradomain and interdomain motions in conferring distinct activation rates to two Gα proteins, Gα(i1)...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3358857/ https://ncbi.nlm.nih.gov/pubmed/22529365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202943109 |
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