AN APOLIPOPROTEIN E4 FRAGMENT AFFECTS MMP9, TIMP1 AND CYTOKINE LEVELS IN BRAIN CELL LINES

Apolipoprotein (apo) E4 isoform, a major risk factor for Alzheimer’s disease (AD), is more susceptible to proteolysis than apoE2 and apoE3 isoforms. ApoE4 fragments have been found in AD patients’ brain. In the present study, we examined the effect of full-length apoE4 and apoE4 fragments apoE4[Δ(18...

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Bibliographic Details
Main Authors: Dafnis, Ioannis, Tzinia, Athina K., Tsilibary, Effie C., Zannis, Vassilis I., Chroni, Angeliki
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358542/
https://ncbi.nlm.nih.gov/pubmed/22445724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2012.03.013
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