LAMTOR1 depletion induces p53-dependent apoptosis via aberrant lysosomal activation

Lysosomal regulation is a poorly understood mechanism that is central to degradation and recycling processes. Here we report that LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and mTOR activator 1) downregulation affects lysosomal activation, through mechanisms that are not solely due to mTORC1 in...

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Detalhes bibliográficos
Main Authors: Malek, M, Guillaumot, P, Huber, A-L, Lebeau, J, Pétrilli, V, Kfoury, A, Mikaelian, I, Renno, T, Manié, S N
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358017/
https://ncbi.nlm.nih.gov/pubmed/22513874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.39
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