PP2A inactivation is a crucial step in triggering apoptin-induced tumor-selective cell killing

Apoptin (apoptosis-inducing protein) harbors tumor-selective characteristics making it a potential safe and effective anticancer agent. Apoptin becomes phosphorylated and induces apoptosis in a large panel of human tumor but not normal cells. Here, we used an in vitro oncogenic transformation assay...

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Bibliografiske detaljer
Main Authors: Zimmerman, R, Peng, D-J, Lanz, H, Zhang, Y-H, Danen-Van Oorschot, A, Qu, S, Backendorf, C, Noteborn, M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358009/
https://ncbi.nlm.nih.gov/pubmed/22476099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.31
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