Apoptin induces apoptosis in human transformed and malignant cells but not in normal cells

The chicken anemia virus protein apoptin induces a p53-independent, Bcl-2-insensitive type of apoptosis in various human tumor cells. Here, we show that, in vitro, apoptin fails to induce programmed cell death in normal lymphoid, dermal, epidermal, endothelial, and smooth-muscle cells. However, when...

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Main Authors: Oorschot, A. A. A. M. Danen-Van, Fischer, D. F., Grimbergen, J. M., Klein, B., Zhuang, S.-M., Falkenburg, J. H. F., Backendorf, C., Quax, P. H. A., Van der Eb, A. J., Noteborn, M. H. M.
格式: Artigo
語言:Inglês
出版: The National Academy of Sciences of the USA 1997
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC20868/
https://ncbi.nlm.nih.gov/pubmed/9159162
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