Apoptin induces apoptosis in human transformed and malignant cells but not in normal cells

The chicken anemia virus protein apoptin induces a p53-independent, Bcl-2-insensitive type of apoptosis in various human tumor cells. Here, we show that, in vitro, apoptin fails to induce programmed cell death in normal lymphoid, dermal, epidermal, endothelial, and smooth-muscle cells. However, when...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Oorschot, A. A. A. M. Danen-Van, Fischer, D. F., Grimbergen, J. M., Klein, B., Zhuang, S.-M., Falkenburg, J. H. F., Backendorf, C., Quax, P. H. A., Van der Eb, A. J., Noteborn, M. H. M.
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1997
Fag:	Biological Sciences
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20868/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9159162/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.11.5843
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