Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers

Multidrug resistance (MDR) remains a primary hindrance to curative cancer therapy. Thus, introduction of novel strategies to overcome MDR is of paramount therapeutic significance. Sequestration of chemotherapeutics in lysosomes is an established mechanism of drug resistance. Here, we show that MDR c...

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Autors principals: Adar, Y, Stark, M, Bram, E E, Nowak-Sliwinska, P, van den Bergh, H, Szewczyk, G, Sarna, T, Skladanowski, A, Griffioen, A W, Assaraf, Y G
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358008/
https://ncbi.nlm.nih.gov/pubmed/22476101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.30
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