Photoactivation of lysosomally sequestered sunitinib after angiostatic treatment causes vascular occlusion and enhances tumor growth inhibition

The angiogenesis inhibitor sunitinib is a tyrosine kinase inhibitor that acts mainly on the VEGF and PDGF pathways. We have previously shown that sunitinib is sequestered in the lysosomes of exposed tumor and endothelial cells. This phenomenon is part of the drug-induced resistance observed in the c...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Nowak-Sliwinska, P, Weiss, A, van Beijnum, J R, Wong, T J, Kilarski, W W, Szewczyk, G, Verheul, H M W, Sarna, T, van den Bergh, H, Griffioen, A W
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669819/
https://ncbi.nlm.nih.gov/pubmed/25675301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.4
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