Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers

Multidrug resistance (MDR) remains a primary hindrance to curative cancer therapy. Thus, introduction of novel strategies to overcome MDR is of paramount therapeutic significance. Sequestration of chemotherapeutics in lysosomes is an established mechanism of drug resistance. Here, we show that MDR c...

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Detalhes bibliográficos
Main Authors: Adar, Y, Stark, M, Bram, E E, Nowak-Sliwinska, P, van den Bergh, H, Szewczyk, G, Sarna, T, Skladanowski, A, Griffioen, A W, Assaraf, Y G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358008/
https://ncbi.nlm.nih.gov/pubmed/22476101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.30
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