Growth Hormone Receptor Deficiency is Associated With a Major Reduction in Pro-aging Signaling, Cancer and Diabetes in Humans

Life span extending mutations in growth signaling pathways protect against age-dependent DNA damage in yeast and decrease insulin resistance and cancer in mice. To test their effect in humans, we monitored for 22 years Ecuadorian subjects with mutations in the growth hormone receptor gene leading to...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Guevara-Aguirre, Jaime, Balasubramanian, Priya, Guevara-Aguirre, Marco, Wei, Min, Madia, Federica, Cheng, Chia-Wei, Hwang, David, Martin-Montalvo, Alejandro, Saavedra, Jannette, Ingles, Sue, de Cabo, Rafael, Cohen, Pinchas, Longo, Valter D.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3357623/
https://ncbi.nlm.nih.gov/pubmed/21325617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3001845
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki