Growth Hormone Receptor Deficiency is Associated With a Major Reduction in Pro-aging Signaling, Cancer and Diabetes in Humans

Life span extending mutations in growth signaling pathways protect against age-dependent DNA damage in yeast and decrease insulin resistance and cancer in mice. To test their effect in humans, we monitored for 22 years Ecuadorian subjects with mutations in the growth hormone receptor gene leading to...

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Detalhes bibliográficos
Main Authors: Guevara-Aguirre, Jaime, Balasubramanian, Priya, Guevara-Aguirre, Marco, Wei, Min, Madia, Federica, Cheng, Chia-Wei, Hwang, David, Martin-Montalvo, Alejandro, Saavedra, Jannette, Ingles, Sue, de Cabo, Rafael, Cohen, Pinchas, Longo, Valter D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3357623/
https://ncbi.nlm.nih.gov/pubmed/21325617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3001845
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