Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells

We compared bona-fide human induced pluripotent stem cells (iPSC) derived from umbilical cord blood (CB) and neonatal keratinocytes (K). As a consequence of both incomplete erasure of tissue-specific methylation and aberrant de novo methylation, CB-iPSC and K-iPSC are distinct in genome-wide DNA met...

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Detalhes bibliográficos
Main Authors: Kim, Kitai, Zhao, Rui, Doi, Akiko, Ng, Kitwa, Unternaehrer, Juli, Cahan, Patrick, Hongguang, Huo, Loh, Yuin-Han, Aryee, Martin J., Lensch, M. William, Li, Hu, Collins, James J., Feinberg, Andrew P., Daley, George Q.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3357310/
https://ncbi.nlm.nih.gov/pubmed/22119740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2052
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