Xenografted Islet Cell Clusters From INSLEA29Y Transgenic Pigs Rescue Diabetes and Prevent Immune Rejection in Humanized Mice

Islet transplantation is a potential treatment for type 1 diabetes, but the shortage of donor organs limits its routine application. As potential donor animals, we generated transgenic pigs expressing LEA29Y, a high-affinity variant of the T-cell costimulation inhibitor CTLA-4Ig, under the control o...

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Detalhes bibliográficos
Main Authors: Klymiuk, Nikolai, van Buerck, Lelia, Bähr, Andrea, Offers, Monika, Kessler, Barbara, Wuensch, Annegret, Kurome, Mayuko, Thormann, Michael, Lochner, Katharina, Nagashima, Hiroshi, Herbach, Nadja, Wanke, Rüdiger, Seissler, Jochen, Wolf, Eckhard
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2012
Assuntos:
Immunology and Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3357306/
https://ncbi.nlm.nih.gov/pubmed/22522620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1325
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