Modeling lethal X-linked genetic disorders in pigs with ensured fertility

Genetically engineered pigs play an indispensable role in the study of rare monogenic diseases. Pigs harboring a gene responsible for a specific disease can be efficiently generated via somatic cell cloning. The generation of somatic cell-cloned pigs from male cells with mutation(s) in an X chromoso...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Matsunari, Hitomi, Watanabe, Masahito, Nakano, Kazuaki, Enosawa, Shin, Umeyama, Kazuhiro, Uchikura, Ayuko, Yashima, Sayaka, Fukuda, Toru, Klymiuk, Nikolai, Kurome, Mayuko, Kessler, Barbara, Wuensch, Annegret, Zakhartchenko, Valeri, Wolf, Eckhard, Hanazono, Yutaka, Nagaya, Masaki, Umezawa, Akihiro, Nakauchi, Hiromitsu, Nagashima, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789933/
https://ncbi.nlm.nih.gov/pubmed/29311328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1715940115
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