Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified Pigs

We have successfully established and characterized a genetically modified pig line with ubiquitous expression of LEA29Y, a human CTLA4-Ig derivate. LEA29Y binds human B7.1/CD80 and B7.2/CD86 with high affinity and is thus a potent inhibitor of T cell co-stimulation via this pathway. We have characte...

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Bibliographic Details
Published in:PLoS One
Main Authors: Bähr, Andrea, Käser, Tobias, Kemter, Elisabeth, Gerner, Wilhelm, Kurome, Mayuko, Baars, Wiebke, Herbach, Nadja, Witter, Kirsti, Wünsch, Annegret, Talker, Stephanie C., Kessler, Barbara, Nagashima, Hiroshi, Saalmüller, Armin, Schwinzer, Reinhard, Wolf, Eckhard, Klymiuk, Nikolai
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866763/
https://ncbi.nlm.nih.gov/pubmed/27175998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155676
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