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Ligand-dependent Exponential Amplification of a Self-Replicating L-RNA Enzyme

A nuclease-resistant RNA enzyme, constructed entirely from L-ribonucleotides, was shown to undergo ligand-dependent, self-sustained replication with exponential growth. The catalytic motif is based on a previously described RNA ligase that can undergo either self- or cross-replication, but had been...

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書目詳細資料
Main Authors: Olea, Charles, Horning, David P., Joyce, Gerald F.
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3357125/
https://ncbi.nlm.nih.gov/pubmed/22551009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja302197x
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