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Ligand-dependent Exponential Amplification of a Self-Replicating L-RNA Enzyme
A nuclease-resistant RNA enzyme, constructed entirely from L-ribonucleotides, was shown to undergo ligand-dependent, self-sustained replication with exponential growth. The catalytic motif is based on a previously described RNA ligase that can undergo either self- or cross-replication, but had been...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3357125/ https://ncbi.nlm.nih.gov/pubmed/22551009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja302197x |
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