Microglial Amyloid-β1-40 Phagocytosis Dysfunction Is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer's Disease

In Alzheimer disease (AD) patient brains, the accumulation of amyloid-β (Aβ) peptides is associated with activated microglia. Aβ is derived from the amyloid precursor protein; two major forms of Aβ, that is, Aβ1-40 (Aβ40) and Aβ1-42 (Aβ42), exist. We previously reported that rat microglia phagocytos...

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Main Authors: Takata, Kazuyuki, Takada, Tetsuya, Ito, Aina, Asai, Mayo, Tawa, Manami, Saito, Yuki, Ashihara, Eishi, Tomimoto, Hidekazu, Kitamura, Yoshihisa, Shimohama, Shun
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi Publishing Corporation 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3357001/
https://ncbi.nlm.nih.gov/pubmed/22645697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/685739
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