Galantamine-induced Amyloid-β Clearance Mediated via Stimulation of Microglial Nicotinic Acetylcholine Receptors

Reduction of brain amyloid-β (Aβ) has been proposed as a therapeutic target for Alzheimer disease (AD), and microglial Aβ phagocytosis is noted as an Aβ clearance system in brains. Galantamine is an acetylcholinesterase inhibitor approved for symptomatic treatment of AD. Galantamine also acts as an...

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Detalhes bibliográficos
Main Authors: Takata, Kazuyuki, Kitamura, Yoshihisa, Saeki, Mana, Terada, Maki, Kagitani, Sachiko, Kitamura, Risa, Fujikawa, Yasuhiro, Maelicke, Alfred, Tomimoto, Hidekazu, Taniguchi, Takashi, Shimohama, Shun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001000/
https://ncbi.nlm.nih.gov/pubmed/20947502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.142356
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