Quantitative analysis of the detergent-insoluble brain proteome in frontotemporal lobar degeneration using SILAC internal standards

A hallmark of neurodegeneration is the aggregation of disease related proteins that are resistant to detergent extraction. In the major pathological subtype of frontotemporal lobar degeneration (FTLD), modified TAR-DNA binding protein 43 (TDP-43), including phosphorylated, ubiquitinated and proteoly...

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Detalhes bibliográficos
Main Authors: Seyfried, Nicholas T., Gozal, Yair M., Donovan, Laura E., Herskowitz, Jeremy H., Dammer, Eric B., Xia, Qiangwei, Ku, Li, Chang, Jianjun, Duong, Duc M., Rees, Howard D., Cooper, Deborah S., Glass, Jonathan D., Gearing, Marla, Tansey, Malú G., Lah, James J., Feng, Yue, Levey, Allan I., Peng, Junmin
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3357000/
https://ncbi.nlm.nih.gov/pubmed/22416763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr2010814
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