Monoubiquitinylation regulates endosomal localization of Lst2, a negative regulator of EGF receptor signaling

Genetic screens performed in worms identified major regulators of the epidermal growth factor receptor (EGFR) pathway, including the ubiquitin ligase Cbl/SLI-1. Here we focus on the less characterized Lst2 protein, and confirm suppression of MAPK signals. Unexpectedly, human Lst2, a monoubiquitinyla...

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Detalhes bibliográficos
Main Authors: Mosesson, Yaron, Chetrit, David, Schley, Leehee, Berghoff, Janina, Ziv, Tamar, Carvalho, Silvia, Milanezi, Fernanda, Admon, Arie, Schmitt, Fernando, Ehrlich, Marcelo, Yarden, Yosef
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356849/
https://ncbi.nlm.nih.gov/pubmed/19460345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2009.03.015
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