Hepatitis C virus epitope exposure and neutralization by antibodies is affected by time and temperature

A recent study with flaviviruses suggested that structural dynamics of the virion impact antibody neutralization via exposure of ostensibly cryptic epitopes. To determine whether this holds true for the distantly related hepatitis C virus (HCV), whose neutralizing epitopes may be obscured by a glyca...

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Hlavní autoři: Sabo, Michelle C., Luca, Vincent C., Ray, Stuart C., Bukh, Jens, Fremont, Daved H., Diamond, Michael S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356770/
https://ncbi.nlm.nih.gov/pubmed/22078164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2011.10.023
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