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Toxic fibrillar oligomers of amyloid-β have cross-β structure

Although amyloid fibers are found in neurodegenerative diseases, evidence points to soluble oligomers of amyloid-forming proteins as the cytotoxic species. Here, we establish that our preparation of toxic amyloid-β(1–42) (Abeta42) fibrillar oligomers (TABFOs) shares with mature amyloid fibrils the c...

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Autores principales: Stroud, James C., Liu, Cong, Teng, Poh K., Eisenberg, David
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356606/
https://ncbi.nlm.nih.gov/pubmed/22547798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1203193109
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